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Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

Authors: I Katsiadaki, T Ellis, L Andersen, P Antczak, E Blaker, N Burden, T Fisher, C Green, B Labram, A Pearson, K Petersen, D Pickford, C Ramsden, A Ronneseth, K Ryder, D Sacker, C Stevens, H Watanabe, H Yamamoto, F Sewell, P Hawkins, H Rufli, R D Handy, S K Maynard, M N Jacobs

Source: Exotoxicology and Environmental Safety, 2021 July  pdf-file

Aquatic toxicity tests with substances that are poorly soluble and consequences for the environmental risk assessment

Authors: G Weyman, H Rufli, L Weltje, E Salinas, M Hamitou

Source: Environmental toxicology and chemistry, 2012 April  pdf-file

Introduction of moribund category to OECD fish acute test and its effect on suffering and LC50-values

Author: H Rufli

Source: Environmental toxicology and chemistry, 2012 Feb  pdf-file

Poster: Use of "moribund" stage in the OECD fish acute toxicity test and its effects on suffering and LC50-values

Author: H Rufli

Source: SETAC-Europe and World conference Berlin, 2012    pdf-file

Can we reduce the number of fish in the OECD acute toxicity test?

Authors: H Rufli, TA Springer

Source: Environmental toxicology and chemistry / SETAC, 2011 Apr  pdf-file

Fish Acute Toxicity Test: The number of animals can be reduced

Authors: H Rufli, TA Springer

Source: www.forschung3r.ch, 2010 Jun   pdf-file

The chironomid acute toxicity test: development of a new test system

Authors: L Weltje, H Rufli, F Heimbach, J Wheeler, M Vervliet-Scheerbaum, M Hamer

Source: Integrated environmental assessment and management, 2010 Apr   pdf-file

Environmental effect assessment for sexual endocrine-disrupting chemicals: Fish testing strategy

Authors: T Knacker, M Boettcher, T Frische, H Rufli, H-C Stolzenberg, M Teigeler, S Zok, T Braunbeck, C Schäfers

Source: Integrated environmental assessment and management, 2010 Oct   pdf-file

Multi-criteria decision analysis of test endpoints for detecting the effects of endocrine active substances in fish full life cycle tests

Authors: M Crane, M Gross, P Matthiessen, GT Ankley, S Axford, P Bjerregaard, R Brown, P Chapman, M Dorgerloh, M Galay-Burgos...

Source: Integrated environmental assessment and management, 2010 Jul  pdf-file

The use of fish cells in ecotoxicology. The report and recommendations of ECVAM Workshop 47

Authors: A Castaño, N Bols, T Braunbeck, P Dierickx, M Halder, B Isomaa, K Kawahara, LEJ Lee, C Mothersill, P Pärt...

Source: Alternatives to laboratory animals : ATLA, 2003 May-Jun    pdf-file

Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)

Authors: T Schmid, J Gonzalez-Valero, H Rufli, DR Dietrich

Source: Toxicology letters, 2002 May    pdf-file

Guidance document on aqueous-phase aquatic toxicity testing of difficult test chemicals. OECD Series on Testing No. 23 (second edition)

Source: OECD Series on Testing and Assessment No. 23, 2018    pdf-file

Aquatic toxicity testing of sparingly soluble, volatile, and unstable substances and interpretation and use of data

Authors: H Rufli, PR Fisk, AE Girling, JM King, R Länge, X Lejeune, N Stelter, C Stevens, P Suteau, J Tapp...

Source: Ecotoxicology and environmental safety, 1998 Feb    pdf-file                                                   

Aquatic toxicity testing of sparingly soluble and volatile substances

Authors: H Rufli, PR Fisk, AE Girling, JM King, R Länge, X Lejeune, N Stelter, C Stevens, P Suteau, J Tapp...

Source: ECETOC Monograph No. 26, 1996 Sept    pdf-file

Poster: Validation of hepatic EROD-activity in Rainbow Trout as a biomarker to assess effluent toxicity of a sewage treatment plant

Authors: H Rufli, W Meier, T Wahli, P Sagelsdorff, H Thomas

Source: Poster at SETAC World Congress, Vancouver, 1995   pdf-file

Ermittlungen der Auswirkungen eines Kläranlagen-Ablaufs auf Wasserorganismen mit Hilfe subchronischer in-situ Biotestverfahren

Authors: H Rufli, S Flury, W Meier, T Wahli, P Sagelsdorff, H Thomas   pdf-file

Source: Ciba-Geigy Internal Report 1994

Poster: Biomonitoring of Effluents

Authors: H Rufli, S Flury

Source: Ciba-Geigy Poster 1993   pdf-file

Studi e ricerche condotti nel bacino del Lago di Lugano, Campagna 1980: Clorofilla

Authors: H Rufli, R Peduzzi

Source: Commisione Internazionale per la protezione delle acque italo-svizzere, 1981    pdf-file

Acoustic assessment of nekton in Lake Tanganyika

Authors: OA Mathisen, H Rufli

Source: FAO, Fishery Research and Development Project, Kigoma, 1981   pdf-file

Preliminary estimate of abundance of pelagic fish stocks of Lake Malawi

Authors: H Rufli, JA Vitullo

Source: FAO, Fishery Expansion Project, Nkhata Bay, 1981    pdf-file

Seasonal abundance and depth distribution of pelagic fish off Nkhata Bay (Lake Malawi)

Author: H Rufli

Source: FAO, Fishery Expansion Project, Nkatha Bay, 1981   pdf-file

Age and growth of Engraulicypris sardella (Lake Malawi)

Authors: H Rufli, J van Lissa

Source: FAO, Fishery Expansion Project, Nkhata Bay, 1980  pdf-file 

Fishery biology and stock assessment in Lake Tanganyika

Authors: DW Chapman, H Rufli, P van Well, F Roest

Source: FAO, Fishery Research and Development Project, 1978    pdf-file

Movements of pelagic fish in Lake Tanganyika

Authors: DW Chapman, H Rufli, P van Well, Z Ndugumbii

Source: FAO, Fishery Research and Development Project. Kigoma, 1976   pdf-file  

Preliminary observations on the biology of Lates spp in Lake Tanganyika around Kigoma

Authors: Z Ndugumbi, H Rufli

Source: FAO, Fishery Research and Development Project. Kigoma, 1976   pdf-file

Ernährung und Wachstum der Felchenpopulationen (Coregonus spp.) des Thuner- und Bielersees

Author: H Rufli

Source: Schweiz. Z. Hydrol. 41/1. 1979    pdf-file

Die heutigen sympatrischen Felchenpopulationen (Coregonus spp.) des Thuner- und Bielersees und ihre Morphologie

Author: H Rufli

Source: Schweiz. Z. Hydrologie 40/1, 1978    pdf-file

PhD-Thesis: Biologie der Coregonen im Thuner- und Bielersee

Author: H Rufli

Source: Dissertation No. 5451, ETH-Zürich, 1975    pdf-file

 

PhD-Thesis: Daten zu Biologie der Coregonen im Thuner- und Bielersee

Author: H Rufli

Source: Dissertation No. 5451, ETH-Zürich, 1975    pdf-file

 

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Expertise of Hans Rufli, Dr. sc. nat. ETH

Year Position
2006-date Adviser in Ecotoxicology to the Korea Institute of Toxicology
1994-2003

Head of Aquatic Ecology Team, Novartis and Syngenta Crop Protection AG, Basel, Switzerland

1989-1994 Project Leader of Biomonitoring-Aquatox, Ciba-Geigy AG, Basel, Switzerland
1982-1989 Study Director in Ecotoxicology, Ciba-Geigy AG, Basel, Switzerland
1981-1982 Limnologist / Biologist, Laboratory for Environmental Research,
Istituto cantonale batterioseriologico, Lugano, Switzerland
1978-1980 Head of Department / Fishery Biologist, Lake Malawi Fishery Expansion Project, *FAO , Malawi, Africa
1977-1978 Head of Department / Fishery Biologist in Aquaculture, Brackishwater Aquaculture Development Centre, *FAO, Java, Indonesia
1975-1977 Head of Department / Fishery Biologist, Lake Tanganyika Fishery Research & Development Project, *FAO, Tanzania, Africa
1969-1974 Research Assistant in Fishery Science, Swiss Federal Institute of Aquatic Science and Technology, ETH / EAWAG, Switzerland
   

Participation at Meetings of International Organizations

Year Event
2003

*ICCA Endocrine Coordination Meetings

2001-2008 *VCI Working Group ‘Ecological Methods’, Task Force ‚Endocrine Effects’
2001-2007 *ECPA/IVA Task Force ‘Endocrine Disruptors’
2001-2003 *CEFIC *EMSG LRI Monitoring Team of the ‘Aquatic Research Programme of the Chronic Effects of Endocrine Disruptors to Fish’
2001-2019 *OECD Expert Consultation on Endocrine Disruptors Testing in Fish and Amphibians, Fish Testing Framework, Test Guidelines Programme
2001 *ECVAM Expert Consultation on ‘The Use of Fish Cells in Environmental
1997-2015 *SETAC Meetings giving Short Courses and Presentations
1993-1996 *ECETOC Chairman of the Task Force "Determination of Ecotoxic Properties of Low Solubility and Unstable Compounds in Water"

  

* Explanation of the Abbreviations used

FAO - Food and Agriculture Organisation of the United Nations

ICCA - International Council of Chemical Associates

VCI - German Chemical Industry Association

IVA - Industrieverband Agrar, Germany

ECPA - European Crop Protection Association

CEFIC - European Chemical Industry Council

OECD - Organisation for Economic Co-Operation and Development

ECVAM - European Center for the Validation of Alternative Methods

SETAC - Society of Environmental Toxicology and Chemistry

ECETOC - European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels

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